Cassia occidentalis Potentiates wound Healing Process in Type-2 Diabetic Rats

Indian Journal of Natural Products,2022,36,1,52-57.DOI:10.5530/ijnp.2022.1.8Published:February 2023Type:Original ArticleAuthors:Rajesh Singh Pawar, Avinash Mandloi, Umesh Kumar Patil, and Shweta Author(s) affiliations:Rajesh Pawar1,2,*, Mandloi1, Patil3, Kumar4 1Pharmacognosy Phytochemistry Laboratory, Faculty Pharmacy, VNS Group Institutions, Bhopal, Madhya Pradesh, INDIA. 2Department Truba Institute 3Department Pharmacognosy, Department Pharmaceutical sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, 4Department General Medicine, All India Medical Sciences, Abstract:Introduction: This work is focus on a cost-effective herbal hydrogel formulation comprising extract, from the leaves Cassia occidentalis L. (Caesalpiniaceae). The highly effective for delayed wound healing due to diabetes. Background: (CO) extensively used in folklore medicine system. It common weed scattered foothills Himalayas West Bengal, South India, Burma Srilanka. Objectives: study aimed explore role (leaf) potential diabetic rats using excision model. Materials Methods: characterization phytoconstituents bioavailability profiles methanolic extract CO (MCO) were investigated High-Performance Liquid Chromatography-Photodiode Array Detector analysis. Insulin resistance was induced by feeding them diet rich fructose hyperglycemia injecting streptozotocin (STZ) at dose 40 mg/kg body weight (bw), intraperitoneally (ip). After confirmation diabetes fasting blood glucose level, induced. Excision activity examined Wistar rats. Results: MCO (5 10%) reduced significantly size. Significant mean epithelialization period, higher hydroxyproline content tensile strength revealed concentrations 5 10% compared control group. Conclusion: These results provide promising baseline information type-2 treatment. Keywords:Biochemical parameters, occidentalis, Hydrogel, Hydroxyproline, HyperglycemiaView:PDF (906.38 KB)